New review paper in Seminars in Neurology: “Pathophysiology and Management of Parkinsonian Tremor”


Parkinson’s tremor is one of the cardinal motor symptoms of Parkinson’s disease. The
pathophysiology of Parkinson’s tremor is different from that of othermotor symptoms
such as bradykinesia and rigidity. In this review, the authors discuss evidence
suggesting that tremor is a network disorder that arises from distinct pathophysiologi-
cal changes in the basal ganglia and in the cerebellothalamocortical circuit. They also
discuss how interventions in this circuitry, for example, deep brain surgery and
noninvasive brain stimulation, can modulate or even treat tremor. Future research
may focus on understanding sources for the large variability between patients in terms
of treatment response, on understanding the contextual factors that modulate tremor
(stress, voluntary movements), and on focused interventions in the tremor circuitry.


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